Drug Monograph

Used in combination with narcotics at times, in order to boost the pain-relieving powers of the ketorolac. Ketorolac is to be used for pain management of short duration only, not to exceed five days for all administration routes of the drug (WebMD, 2012. Mayo Foundation for Medical Education and Research, 2012. The American Society of Health-System Pharmacists, 2012. US National Library of Medicine, 2010. FADavis, n.d.. Selleck Chemicals, 2011. MediResource, 2012. MedicineNet, 2012. NetDoctor, 2012. Drugs.com, 2012. RxList, 2012. MedIndia, 2012).
Ketorolac belongs to the same class of drugs as ibuprofen as well as naproxen, but the consensus is that ketorolac has greater power in the reduction of pain from inflammation as well as from other causes. This makes ketorolac singular among other NSAIDs, with regard to the degree of effect and with regard to the kinds of pain that it can relieve or treat. It works by effecting the blockage of those enzymes responsible for the production of prostaglandins in the body, those chemicals that the body generates that in turn results in fever and inflammation (MedicineNet, 2012).
The first dose can be via the veins, or via the muscles, administered via injections (US National Library of Medicine, 2010). The typical subsequent dose is 10 mg for every four to six hours in the presence of pain, depending on the requirement for pain relief. The recommended maximum daily dose is 40 mg, to be taken preferably with meals, in order to reduce risks of stomachs getting upset from the medication (MediResource, 2012). Some dosage prescriptions are age and weight dependent, as well as dependent on the presence of some other conditions, such as impairment of the urine function (Roche Laboratories, 2008):
Transition from IV or IM dosing of ketorolac tromethamine (single- or multiple-dose) to multiple-dose TORADOLORAL: Patients age 17 to 64: 20 mg PO once followed by 10 mg q4-6 hours prn