Pathophosiology of sepsis

Pathophysiology of Sepsis Sepsis is one of the most crucial concerns for the modern scientists and doctors. Coagulation system of patients with sepsis suffers greatly. Sepsis is a dreadful disease, which causes not only a harmful effect on appearance, but also on vitals. Moreover, there is no doubt that activated protein C is the most perfect means for treatment patients with severe sepsis. In previous years it was believed that sepsis was an exaggerated, hyperinflammatory reaction to inflammation-induced organ injury.
There are equal symptoms of the way sepsis inflames skin tissues. Thus, it is relevant to take control over body temperature, heartbeat and other indicators of a potential threat of sepsis. A presence of two of the following four factors can indicate sepsis:
temperature &gt.38ÂșC or 90 beats/min
respiratory rate &gt.20 breaths/min or PaCO2 12,000 cells/mm3, 10 percent immature (band) forms (Sibbald, Neviere, 2000).
Nowadays the scientists are persuaded by the fact that inflammatory response of septic patients is the result of either immuno-stimulation or immune-suppression. Such kind of cells, as neutrophils remains activated, though other changes in cells can be accelerated in a negative way (Sibbald, Neviere, 2000). Consequently, it is relevant to look for effective means of sepsis treatment. Metabolic changes are present, though they require a scrutinized and detailed monitoring. From this perspective, medical literature outlines that there is no a single mediator/system/pathway/pathogen, triggering the pathophysiology of sepsis. Sepsis is a vicious disease, because it cannot be properly controlled and it is really hard to regulate it or sustain a process of medical treatment of it. The most challenging aspect of the disease is that there is a direct interaction between the cells and infection is transferred from one cell to another. Organ injury is essential and patients suffer much from excessive skin inury, immunosuppression and anergy. Moreover, sepsis can lead to the multiple organ dysfunction syndromes (MODS) (Sibbald, Neviere, 2000). Therefore, it is relevant to take control over inflammatory processes, when different tissues are subjected to infection.
Sibbald, W. J., Neviere, R. (Jan. 06, 2000). Pathophysiology of Sepsis. Retrieved July 07, 2012 from: