Patients with respiratory diseases such as occupational and environmental lung diseases, fibrosing lung diseases, chronic lung infections, cystic fibrosis, and acute respiratory failure among others often experience difficulty in breathing and sleeping disorders. Within the respiratory wards, nurses play a critical role in providing a good delivery of health care services to patients and minimizing the spread of contagious diseases through proper handwashing techniques. Concerning the handling of respiratory care for patients, each nurse should be knowledgeable not only with the basic health care provision for patients with respiratory diseases or illnesses but also the ethical principles and legality of the nursing practice in order to avoid facing legal charges from these patients. This study will discuss the basic aspect of nursing knowledge particularly in the organization of care in personal hygiene and infection control within the respiratory ward. The necessary skill mix of nurses working in the respiratory ward particularly the importance of combined skills, knowledge, and attitude (SKUs) in the nursing profession will be noted. Upon analyzing the importance of personal hygiene and infection control, the author will incorporate the King’s Goal Attainment Theory model in explaining why it is necessary to provide the patients with proper personal hygiene particularly the need for handwashing and implement infection control measures within the respiratory ward. The study will also mention some of the contributions of several nursing theorists such as Martha Rogers (1950s). Virginia Henderson (1966). Rosemarie Parse (1992). Nightingale (1969). Roper et al. (1980s). and Orem (1980) in personal hygiene and infection control within the respiratory ward. Personal hygiene refers to the physical act of cleaning the body to ensure that hair, skin, oral, and nails are in good condition and free from infection.